Illnesses Causing Hyperpigmentation

Some types of hyperpigmentation are caused by certain illnesses, such as Peutz-Jeghers syndrome, where spots appear on the lips, xeroderma pigmentosum, or Leopard syndrome.  Addison’s disease, an adrenal disorder, excessive amounts of iron in the blood, and cirrhosis can also cause skin discolorations.  Certain drugs will also promote skin darkening, including antimalarials, chemotherapy drugs, phenothiazines and tetracyclines.  The hue of the discoloration can denote the specific type of drugs to which the body is reacting. Drugs creating excessive melanin in the epidermis will create a brown discoloration, while melanin over production in the dermis will produce a hue that displays a blue hue.